ON THE RELATIONSHIP BETWEEN THE NUMBER OF NEGATIVE SLOPE REGIONS IN THE VOLTAGE-CURRENT CURVE OF THE HODGKIN-HUXLEY MODEL AND ITS PARAMETER VALUES

被引：19

作者：

BEDROV, YA ^{[1
]}

AKOEV, GN ^{[1
]}

DICK, OE ^{[1
]}

机构：

[1] RUSSIAN ACAD SCI,IP PAVLOV PHYSIOL INST,DEPT PHYSIOL RECEPT,ST PETERSBURG 199034,RUSSIA

来源：

BIOLOGICAL CYBERNETICS | 1995年 / 73卷 / 02期

关键词：

D O I：

10.1007/BF00204053

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

We consider the problem of the existence of a negative slope region (NSR) in the voltage-current curve of the neuronal membrane and the relationship between this phenomenon and the membrane parameters. For the Hodgkin-Huxley model it is proposed to determine the dependence of the number of NSR on the values of the maximal sodium (<(g)over bar (Na)>) and potassium (<(g)over bar (K)>) conductances. The method is suggested for constructing the boundaries on the (<(g)over bar (Na)>, <(g)over bar (K)>) plane, in passing through which the number of NSR changes to 1. Using the method we partition the (<(g)over bar (Na)>, <(g)over bar (K)>) plane into the regions corresponding to the curves with the different number of NSR. This number can be changed from 0 to 2 in changing the values of <(g)over bar (Na)> and <(g)over bar (K)> over the physiologically possible range.

引用

页码：149 / 154

页数：6

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