AN INTERNATIONAL COLLABORATIVE CASE-CONTROL STUDY OF SEVERE CUTANEOUS ADVERSE REACTIONS (SCAR) - DESIGN AND METHODS

被引：58

作者：

KELLY, JP

AUQUIER, A

RZANY, B

NALDI, L

BASTUJIGARIN, S

CORREIA, O

SHAPIRO, S

KAUFMAN, DW

机构：

[1] INST GUSTAVE ROUSSY,DEPT BIOSTAT & EPIDEMIOL,INSERM,U351,VILLEJUIF,FRANCE

[2] UNIV FREIBURG,DEPT DERMATOL,W-7800 FREIBURG,GERMANY

[3] UNIV MILAN,BERGAMO GEN HOSP,DEPT DERMATOL,ITALIAN GRP EPIDEMIOL RES DERMATOL,COORDINATING C,BERGAMO,ITALY

[4] UNIV PARIS 12,HOP HENRI MONDOR,DEPT PUBL HLTH,F-94010 CRETEIL,FRANCE

[5] HOSP SAO JOAO,FAC MED,DEPT IMMUNOL,OPORTO,PORTUGAL

[6] HOSP SAO JOAO,FAC MED,DEPT DERMATOL VENEROL,OPORTO,PORTUGAL

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 1995年 / 48卷 / 09期

关键词：

EPIDEMIOLOGY; STEVENS-JOHNSON SYNDROME; TOXIC EPIDERMAL NECROLYSIS; ETIOLOGY; CASE-CONTROL; ADVERSE DRUG REACTIONS;

D O I：

10.1016/0895-4356(95)00004-N

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

A multicenter international case-control study has been designed to elucidate the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis (TEN). Although these diseases occur rarely, the morbidity is high and the mortality for TEN is of the order of 30%. These serious dermatologic conditions have often been linked to exposure to drugs. Infective and autoimmune diseases, as well as other non-drug risk factors, have also been postulated to be of importance in increasing the risk. The design and methods are described, with particular attention to the unique challenges for an epidemiologic study of these conditions.

引用

页码：1099 / 1108

页数：10

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[1] TOXIC EPIDERMAL NECROLYSIS - A REVIEW [J].