RENAL FILTRATION AND EXCRETION OF ALUMINUM IN THE RAT - DOSE-RESPONSE RELATIONSHIPS AND EFFECTS OF ALUMINUM SPECIATION

被引:8
作者
LOTE, CJ
WOOD, JA
THEWLES, A
FREEMAN, M
机构
[1] Department of Physiology, Medical School, University of Birmingham, Birmingham
来源
HUMAN & EXPERIMENTAL TOXICOLOGY | 1995年 / 14卷 / 06期
基金
英国惠康基金;
关键词
ALUMINUM; CITRATE; SULFATE; KIDNEY;
D O I
10.1177/096032719501400605
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
The known toxicity of aluminium, and the toxicity of agents (such as desferrioxamine) used to remove aluminium from the body, has prompted us to investigate whether there may be ways of enhancing aluminium excretion by exploiting the normal renal handling of aluminium. Aluminium (as sulphate or citrate) was administered intravenously to conscious rats at doses ranging from 25 mu g (0.93 mu mol) to 800 mu g (29.6 mu mol) aluminium, and aluminium excretion was monitored over the following 2 h. Measurements of the filterability of aluminium from the rat plasma, and the glomerular filtration rate (inulin clearance), enabled us to calculate the filtered load of aluminium, and hence determine aluminium reabsorption. At all doses of administered aluminium, that administered as sulphate was excreted less effectively than that administered as citrate. This difference was attributable to the much greater filterability of aluminium administered as citrate. However, for any given filtered load, the excretion of aluminium administered as citrate was not significantly different (in either fractional or absolute terms) from the excretion of aluminium administered as sulphate. It seems likely that, following aluminium sulphate administration, the filtered aluminium may be an aluminium citrate form which is then reabsorbed in the same way as aluminium administered as citrate. It is thus apparent that aluminium removal from the body could be further enhanced if it were possible to prevent the tubular reabsorption of the aluminium species which is so effectively filtered following aluminium citrate administration.
引用
收藏
页码:494 / 499
页数:6
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