A PROTECTIVE EFFECT OF LITHIUM ON RAT BEHAVIOR ALTERED BY IBOTENIC ACID LESIONS OF THE BASAL FOREBRAIN CHOLINERGIC SYSTEM

被引：36

作者：

PASCUAL, T

GONZALEZ, JL

机构：

[1] UNIV VALLADOLID,FAC MED,EXPTL & CLIN NEUROPHARMACOL LAB,VALLADOLID,SPAIN

[2] UNIV VALLADOLID HOSP,VALLADOLID,SPAIN

来源：

BRAIN RESEARCH | 1995年 / 695卷 / 02期

关键词：

EXCITATORY AMINO-ACID; LITHIUM; PASSIVE AVOIDANCE; NEUROTOXICITY; BASAL FOREBRAIN;

D O I：

10.1016/0006-8993(95)00934-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lithium was tested on an animal model of a brain cholinergic excitotoxic lesion. Male Wistar rats received unilaterally 50 nmol ibotenic acid in the nucleus basalis magnocellularis. Some were treated intraperitoneally with LiCl from two days before to six days after lesioning. Such treated rats showed less deficits than untreated lesioned animals on passive avoidance, ambulatory behaviour and choline acetyltransferase activity in the lesioned cortex. Lithium protection against excitatory amino acid neurotoxicity is suggested.

引用

页码：289 / 292

页数：4

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