Molecular determinants of Alzheimer's disease A beta peptide neurotoxicity

被引：8

作者：

Cappai, Roberto ^{[1
]}

Barnham, Kevin J. ^{[2
]}

机构：

[1] Univ Melbourne, Mol Sci & Biotechnol Inst Bio21, Dept Pathol, Melbourne, Vic 3010, Australia

[2] Mental Hlth Res Inst Victoria, Parkville, Vic 3052, Australia

来源：

FUTURE NEUROLOGY | 2007年 / 2卷 / 04期

关键词：

A beta; Alzheimer's disease; amyloid; metal; neurodegeneration; oligomer; oxidative stress; synapse; tau; toxicity;

D O I：

10.2217/14796708.2.4.397

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Alzheimer's disease amyloid precursor protein is sequentially processed to yield the neurotoxic amyloid-beta (A beta) peptide, which is the principal component of the senile plaques in Alzheimer's disease brains. This review will outline the current thinking on how A beta mediates neurotoxicity or neuronal dysfunction. In particular, this article will focus on the key residues that modulate A beta's activity and the cellular pathways and mechanisms involved. It will detail how A beta-metal interactions are a key determinate in Alzheimer's disease pathogenesis.

引用

页码：397 / 409

页数：13

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