SYNTHESIS OF C-FUCOPYRANOSYL ANALOGS OF GDP-L-FUCOSE AS INHIBITORS OF FUCOSYLTRANSFERASES

被引：45

作者：

LUENGO, JI

GLEASON, JG

机构：

[1] Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Swedeland, PA 19479

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(00)60893-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The syntheses of the C-fucopyranosyl analogs of GDP-L-fucose 2 - 5 as potential inhibitors of fucosyltransferases are reported. The synthetic routes are based on the C-glycosidation of tetra-O-acetyl-alpha-L-fucopyranose 6 under conditions that provided either beta- or alpha- C-fucosides with high stereoselectivity. Coupling to GMP was effected by Khorana's phosphomorpholidate method.

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页码：6911 / 6914

页数：4

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