AL-26 TRACER EXPERIMENT BY ACCELERATOR MASS-SPECTROMETRY AND ITS APPLICATION TO THE STUDIES FOR AMYOTROPHIC-LATERAL-SCLEROSIS AND ALZHEIMERS-DISEASE .1.

被引：38

作者：

KOBAYASHI, K

YUMOTO, S

NAGAI, H

HOSOYAMA, Y

IMAMURA, M

MASUZAWA, S

KOIZUMI, Y

YAMASHITA, H

机构：

[1] UNIV TOKYO,FAC MED,DEPT ANAT,BUNKYO KU,TOKYO 113,JAPAN

[2] NIHON UNIV,COLL HUMANITIES & SCI,SETAGAYA KU,TOKYO 156,JAPAN

[3] UNIV TOKYO,INST NUCL STUDY,TOKYO 188,JAPAN

[4] UNIV TOKYO,CTR RADIOISOTOPE,BUNKYO KU,TOKYO 113,JAPAN

[5] UNIV TOKYO,FAC SCI,DEPT PHYS,BUNKYO KU,TOKYO 113,JAPAN

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 1990年 / 66卷 / 10期

关键词：

ACCELERATOR MASS SPECTROMETRY; AMYOTROPHIC LATERAL SCLEROSIS; ALZHEIMERS DISEASE; AL-26; TRACER; ALUMINUM TOXICITY;

D O I：

10.2183/pjab.66.189

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Accelerator mass spectrometry (AMS) was applied for Al-26 tracer experiment to study the aluminum toxicity and metabolism in rats. To investigate the cause of amyotrophic lateral sclerosis (ALS) and Alzheimer's disease, the aluminum incorporation into the brain (cerebrum) was studied by AMS using Al-26 as a tracer. When Al-26 was intraperitoneally injected into rats, a considerable amount of Al-26 was incorporated into the cerebrum after 5-35 days of the injection.

引用

页码：189 / 192

页数：4

共 14 条

[1] INTRANUCLEAR ALUMINUM CONTENT IN ALZHEIMERS-DISEASE, DIALYSIS ENCEPHALOPATHY, AND EXPERIMENTAL ALUMINUM ENCEPHALOPATHY [J].