OSTEOMALACIA IN PAGETS-DISEASE TREATED WITH SHORT-TERM, HIGH-DOSE SODIUM ETIDRONATE

被引：60

作者：

GIBBS, CJ ^{[1
]}

AARON, JE ^{[1
]}

PEACOCK, M ^{[1
]}

机构：

[1] GEN INFIRM, MRC, MINERAL METAB UNIT, LEEDS LS1 3EX, W YORKSHIRE, ENGLAND

来源：

BMJ-BRITISH MEDICAL JOURNAL | 1986年 / 292卷 / 6530期

关键词：

D O I：

10.1136/bmj.292.6530.1227

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Eleven patients with Paget''s disease treated with sodium etidronate 20 mg/kg per day for two and four weeks showed significant reductions in plasma alkaline phosphatase activity and urinary hydroxyproline excretion, both of which are biochemical markers of bone turnover. After four weeks of treatment however, histological examination of iliac crest biopsy samples showed that despite a rapid reduction in bone resorption there was an appreciable mineralisation defect; even after only two weeks'' treatment the abnormalities in bone formation persisted for up to 10 weeks.

引用

页码：1227 / 1229

页数：3

共 14 条

[1]

AARON J, 1976, CALCIUM PHOSPHATE MA, P564

[2] STAINING OF THE CALCIFICATION FRONT IN HUMAN-BONE USING CONTRASTING FLUOROCHROMES INVITRO [J].

AARON, JE ;

MAKINS, NB ;

FRANCIS, RM ;

PEACOCK, M .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1984, 32 (12) :1251-1261

[3]

BOYCE BF, 1984, LANCET, V1, P821

[4] MEASUREMENT OF THE FASTING URINARY HYDROXYPROLINE - CREATININE RATIO IN NORMAL ADULTS AND ITS VARIATION WITH AGE AND SEX [J].

HODGKINSON, A ;

THOMPSON, T .

JOURNAL OF CLINICAL PATHOLOGY, 1982, 35 (08) :807-811

[5] PAGETS-DISEASE OF BONE - DIAGNOSIS AND MANAGEMENT [J].

KANIS, JA ;

EVANSON, JM ;

RUSSELL, RGG .

METABOLIC BONE DISEASE & RELATED RESEARCH, 1981, 3 (4-5) :219-230

[6]

KHAIRI MRA, 1977, CALC TISS RES, V22, P355

[7] SODIUM ETIDRONATE IN TREATMENT OF PAGETS-DISEASE OF BONE - STUDY OF LONG-TERM RESULTS [J].

KHAIRI, MRA ;

ALTMAN, RD ;

DEROSA, GP ;

ZIMMERMANN, J ;

SCHENK, RK ;

JOHNSTON, CC .

ANNALS OF INTERNAL MEDICINE, 1977, 87 (06) :656-663

[8] INFLUENCE OF A DIPHOSPHONATE ON THE CELLULAR ASPECT OF YOUNG BONE TISSUE [J].

PLASMANS, CMT ;

JAP, PHK ;

KUIJPERS, W ;

SLOOFF, TJJH ;

WIJERS, M .

CALCIFIED TISSUE INTERNATIONAL, 1980, 32 (03) :247-256

[9] EFFECTIVE SHORT-TERM TREATMENT OF PAGETS-DISEASE WITH ORAL ETIDRONATE [J].

PRESTON, CJ ;

YATES, AJP ;

BENETON, MNC ;

RUSSELL, RGG ;

GRAY, RES ;

SMITH, R ;

KANIS, JA .

BRITISH MEDICAL JOURNAL, 1986, 292 (6513) :79-80

[10]

RUSSELL RGG, 1974, LANCET, V1, P894

← 1 2 →