DETERMINATION OF TENOXICAM IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：22

作者：

MUNERAJARAMILLO, MI

BOTEROGARCES, S

机构：

[1] Clinical Pharmacology Unit, Corporación para Investigaciones Biológicas C.I.B., Medellín

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 616卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80407-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A high-performance liquid chromatographic technique with a lower detection limit for measuring tenoxicam plasma levels was standardized. Tenoxicam was extracted with dichloromethane from acidified plasma and the evaporated extracts were analysed on a reversed-phase column using a methanol-phosphate buffer mobile phase and setting ultraviolet detection at 355 nm. A reproducible calibration curve in the 5-2000 ng/ml range was obtained. The mean recovery of extraction was 98.99 +/- 4.3% and the detection limit was 5 ng/ml.

引用

页码：349 / 352

页数：4

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