EFFECT OF CATIONIC GROUPS ON THE ADHESIVITY OF PERITONEAL-MACROPHAGES TO POLYMERIC BEADS

被引：8

作者：

SMETANA, K

JELINKOVA, M

VACIK, J

NOVAK, M

机构：

[1] ACAD SCI CZECH REPUBL,INST MACROMOLEC CHEM,PRAGUE,CZECH REPUBLIC

[2] CENT MIL INST MED,PRAGUE,CZECH REPUBLIC

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1995年 / 6卷 / 01期

关键词：

D O I：

10.1007/BF00121244

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study demonstrates the adhesion of macrophages to polymer beads from a copolymer of hydroxyethyl methacrylate and dimethyl aminoethyl methacrylate intraperitoneally injected into the rat. Dimethyl aminoethyl methacrylate exhibited a stimulatory effect on macrophage adhesion 5 h after injection of the beads. Electron microscopy demonstrated protein adsorption on the surface of the beads. Protein fibres between the cell surface and beads were observed. The experimental system used minimizes the influence of tissue damage at macrophage recognition of polymers. This method seems to be suitable for short-term investigation of macrophage-polymer interaction.

引用

页码：32 / 34

页数：3

共 14 条

[1]

CHENOWETH DE, 1987, ANN NY ACAD SCI, V516, P306

[2]

COUPEK J, 1973, J POLYM SCI POL SYM, P185

[3] IDENTIFICATION OF MACROPHAGE CELL-SURFACE BINDING-SITES FOR CATIONIZED BOVINE SERUM-ALBUMIN [J].