Transcriptional regulation and transpositional selection of active SINE sequences

被引：150

作者：

Schmid, Carl ^{[1
]}

Maraia, Richard ^{[2
]}

机构：

[1] Univ Calif Davis, Dept Genet & Chem, Davis, CA 95616 USA

[2] NICHHD, Lab Mol Growth Regulat, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1992年 / 2卷 / 06期

关键词：

5-methyl cytosine; !sup]m[!/sup]C; IAP; intracisternal A-particle; LINE; long interspersed element; pol III; polymerase III; reverse transcriptase; RT; short interspersed element; SINE;

D O I：

10.1016/S0959-437X(05)80110-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alu repeats are short interspersed elements whose transpostition has lead to genetic variability and heritable disorders in humans. A select subset of the nearly one million Alu sequences in human DNA actually produce new transpositions. The evolution of newly inserted Alu repeats is currently a key subject for study. Mechanisms of RNA polymerase III activity and the sequence environment into which an Alu inserts might select for transcriptional and posttranscriptional determinants of Alu transposition.

引用

页码：874 / 882

页数：9

共 61 条

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