INHIBITION OF LUNG DAMAGE CAUSED BY PARAQUAT WITH LYMPHOKINES OR CYTOKINES

被引：2

作者：

BARABAS, K ^{[1
]}

SERENYI, P ^{[1
]}

SELYPES, A ^{[1
]}

机构：

[1] COUNTRY HOSP, DEPT PATHOL, KECSKEMET, HUNGARY

来源：

EXPERIMENTAL PATHOLOGY | 1990年 / 38卷 / 03期

关键词：

cytokines; fibrosis; lung; lung damage; lymphokine-enriched supernatant; lymphokines; paraquat;

D O I：

10.1016/S0232-1513(11)80208-2

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gramoxone®, containing paraquat as an active ingredient can cause severe lung injury in both humans and experimental animals. Biologically active fibroblast-stimulating factors produced by lymphocytes and macrophages may be of importance in the development of interstitial fibrosis. In our present study we have attempted to inhibit the process of paraquat induced lung fibrosis by lymphokine-enriched supernatants from concanavalin A stimulated spleen cell cultures. It was found that adequate supernatant treatment significantly reduced PQ-induced lung injury and its associated inflammatory response. © 1990, VEB Gustav Fischer Verlag Jena. All rights reserved.

引用

页码：189 / 195

页数：7

共 8 条

[1] SUPEROXIDE-CATALYZED AND SINGLET OXYGEN-CATALYZED LIPID PEROXIDATION AS A POSSIBLE MECHANISM FOR PARAQUAT (METHYL VIOLOGEN) TOXICITY [J].