The preparation and application of a K+, Na+ and Cl- integrated microconduit potentiometric analytical system with tubular ion-selective electrodes (ISEs), microvalve, chemfold, electrostatic and pulse inhibitors is described. Electrochemical characteristics of the tubular ISEs and integrated microconduit FIA-ISEs were studied. The contents of K+, Na+ and Cl- in soil, water and serum were determined with the device. The analytical results agreed well with those obtained by flame photometric and silver nitrate volumetric methods.