EFFECT OF ATHEROSCLEROSIS ON CEREBRAL VASCULAR-RESPONSES TO ACTIVATION OF LEUKOCYTES AND PLATELETS IN MONKEYS

被引:29
作者
FARACI, FM
LOPEZ, JAG
BREESE, K
ARMSTRONG, ML
HEISTAD, DD
机构
[1] UNIV IOWA,COLL MED,CTR CARDIOVASC,DEPT PHARMACOL,IOWA CITY,IA 52242
[2] UNIV IOWA,COLL MED,VET ADM MED CTR,IOWA CITY,IA 52242
关键词
CEREBRAL BLOOD FLOW; RETINA; PROSTAGLANDINS-E; MONKEYS;
D O I
10.1161/01.STR.22.6.790
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The goal of this study was to test the hypothesis that atherosclerosis alters responses of cerebral arteries and the ocular circulation to the activation in vivo of leukocytes and platelets. We measured blood flow to the brain and eye using microspheres and pressure in the cerebral microvessels of normal and atherosclerotic monkeys. The intracarotid injection of 10(-7) M N-formyl-L-methionyl-L-leucyl-L-phenylalanine to activate leukocytes did not alter cerebral blood flow in 11 normal or 10 atherosclerotic monkeys but increased the resistance of large cerebral arteries by 46 +/- 11% (mean +/- SEM) in the atherosclerotic animals. The injection of N-formyl-L-methionyl-L-leucyl-L-phenylalanine did not alter blood flow to the eye in 10 normal monkeys but decreased blood flow to the choroid by 38 +/- 9% in 11 atherosclerotic monkeys. The intracarotid injection of 3 x 10(-9) M prostaglandin E2, a leukocyte product, produced an increase in the resistance of large cerebral arteries in five atherosclerotic but not in six normal monkeys. Prostaglandin E2 reduced blood flow to the retina and choroid in the atherosclerotic monkeys by 62 +/- 22% and 65 +/- 17%, respectively. The intracarotid infusion of 25-mu-g/min collagen to activate platelets increased cerebral blood flow by 21 +/- 5% in 10 normal monkeys but did not alter it in 11 atherosclerotic monkeys. Collagen did not alter blood flow to the choroid in 10 normal monkeys but decreased it by 29 +/- 8% in 11 atherosclerotic monkeys. Thus, atherosclerosis potentiates the constrictor responses of large cerebral arteries and blood vessels of the eye to leukocyte activation and prostaglandin E2 and impairs the cerebral vasodilator responses to platelet activation in vivo.
引用
收藏
页码:790 / 796
页数:7
相关论文
共 28 条
[1]   VASODILATION OF CAT CEREBRAL ARTERIOLES BY PROSTAGLANDINS D2, E2, G2, AND I2 [J].
ELLIS, EF ;
WEI, EP ;
KONTOS, HA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 237 (03) :H381-H385
[2]   REGULATION OF LARGE CEREBRAL-ARTERIES AND CEREBRAL MICROVASCULAR PRESSURE [J].
FARACI, FM ;
HEISTAD, DD .
CIRCULATION RESEARCH, 1990, 66 (01) :8-17
[3]   ATHEROSCLEROSIS POTENTIATES CONSTRICTOR RESPONSES OF CEREBRAL AND OCULAR BLOOD-VESSELS TO THROMBOXANE IN MONKEYS [J].
FARACI, FM ;
WILLIAMS, JK ;
BREESE, KR ;
ARMSTRONG, ML ;
HEISTAD, DD .
STROKE, 1989, 20 (02) :242-247
[4]   RESPONSES OF RAT BASILAR ARTERY TO ACETYLCHOLINE AND PLATELET PRODUCTS INVIVO [J].
FARACI, FM ;
MAYHAN, WG ;
HEISTAD, DD .
STROKE, 1991, 22 (01) :56-60
[5]  
GOWN AM, 1986, AM J PATHOL, V125, P191
[6]   P1-PURINE AND P2-PURINE RECEPTORS IN BRAIN CIRCULATION [J].
HARDEBO, JE ;
KAHRSTROM, J ;
OWMAN, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 144 (03) :343-352
[7]   EFFECTS OF PROSTAGLANDINS AND ARACHIDONIC-ACID ON BABOON CEREBRAL AND MESENTERIC-ARTERIES [J].
HAYASHI, S ;
PARK, MK ;
KUEHL, TJ .
PROSTAGLANDINS, 1986, 32 (04) :587-596
[8]   SUPER-SENSITIVITY OF ATHEROSCLEROTIC RABBIT AORTA TO ERGONOVINE - MEDIATION BY A SEROTONERGIC MECHANISM [J].
HENRY, PD ;
YOKOYAMA, M .
JOURNAL OF CLINICAL INVESTIGATION, 1980, 66 (02) :306-313
[9]   SUPEROXIDE ANION IS AN ENDOTHELIUM-DERIVED CONTRACTING FACTOR [J].
KATUSIC, ZS ;
VANHOUTTE, PM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (01) :H33-H37
[10]   OXYGEN RADICALS MEDIATE THE CEREBRAL ARTERIOLAR DILATION FROM ARACHIDONATE AND BRADYKININ IN CATS [J].
KONTOS, HA ;
WEI, EP ;
POVLISHOCK, JT ;
CHRISTMAN, CW .
CIRCULATION RESEARCH, 1984, 55 (03) :295-303