PAIN AT THE INJECTION SITE OF SUBCUTANEOUSLY ADMINISTERED ERYTHROPOIETIN IN MAINTENANCE HEMODIALYSIS-PATIENTS - A COMPARISON OF 2 BRANDS OF ERYTHROPOIETIN

被引：32

作者：

VEYS, N ^{[1
]}

VANHOLDER, R ^{[1
]}

LAMEIRE, N ^{[1
]}

机构：

[1] STATE UNIV GHENT HOSP, DEPT NEPHROL, DE PINTELAAN 185, B-9000 Ghent, BELGIUM

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1992年 / 12卷 / 1-2期

关键词：

ERYTHROPOIETIN; HEMODIALYSIS; LOCAL PAIN; SUBCUTANEOUS ADMINISTRATION;

D O I：

10.1159/000168420

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Local pain due to subcutaneous erythropoietin (EPO) injection into the thigh was studied using a verbal score ranging from 0 to 4. Equivoluminous doses of epoetin-alpha (Cilag) and epoetin-beta (Boehringer) were compared in 2 controlled single-blind experiments: 10 dialysis patients were treated at random for 4 weeks at consecutive sessions with both brands of EPO, and 40 patients were treated in 1 session only with the 2 brands simultaneously. Pain scores were 1.12 +/- 0.28 versus 0.15 +/- 0.06 (p < 0.05) and 1.75 +/- 0.19 versus 0.08 +/- 0.04 for epoetin-alpha and epoetin-beta, respectively (p < 0.001). Treatment acceptance was 48% for epoetin-alpha versus 83% for epoetin-beta (p < 0.05).

引用

页码：68 / 72

页数：5

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