Glutathione peroxidase and oxidative stress

被引：48

作者：

Doroshow, JH

机构：

[1] Department of Medical Oncology, Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

glutathione peroxidase; anthracyclines; doxorubicin; hydrogen peroxide; selenium;

D O I：

10.1016/0378-4274(95)03570-2

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In this study, overexpression of the cDNA for the major cytoplasmic glutathione peroxidase isoenzyme, GSH Peroxidase 1 (GSHPx-1), in human MCF-7 breast cancer cells has been shown to significantly increase the tolerance of these cells to oxidative stress produced by hydrogen peroxide or by the redox cycling of the quinone-containing anticancer agent doxorubicin. These experiments suggest that intracellular detoxification of hydrogen peroxide by the glutathione-glutathione peroxidase cycle plays a critical role in resistance against oxidant stress produced by xenobiotics.

引用

页码：395 / 398

页数：4

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