GONADAL-STEROID HORMONES AND HYPOTHALAMIC OPIOID CIRCUITRY

被引:58
作者
HAMMER, RP
ZHOU, L
CHEUNG, S
机构
[1] TUFTS UNIV,SCH MED,CTR RES REPROD,BOSTON,MA 02111
[2] SAN DIEGO STATE UNIV,DEPT PSYCHOL,SAN DIEGO,CA 92182
关键词
D O I
10.1006/hbeh.1994.1040
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Endogenous Opioid peptides derived from several gene families are localized within hypothalamic regions known to be involved in the regulation of reproduction. For example, the proenkephalin gene products, met- and leu-enkephaiin, and the proopiomelanocortin (POMC) gene product, beta-endorphin, are found in the rat medial preoptic area (MPOA). Moreover, the expression of these peptides and their receptors varies across the estrous cycle in the female rat. We have examined the gonadal steroid regulation of mu-opiate receptors and opioid peptides in the MPOA, and POMC mRNA expression in neurons that innervate the MPOA. mu-Opiate receptors in the MPOA are sexually dimorphic and gonadal steroid hormone-dependent. Hormonal priming of ovariectomized rats with estrogen and progesterone (P) upregulates MPOA mu-receptors 27, but not 3, hr after P treatment. Inhibition of protein synthesis during the first 6 hr after P prevents receptor upregulation. The density of beta-endorphin fibers in the MPOA also increases following hormone treatment, and POMC mRNA expression in neurons that innervate the MPOA is induced by hormone treatment beginning 13 hr after P treatment. This delayed response might be ubiquitous among POMC neurons, as those innervating the median eminence also exhibit increased POMC mRNA expression along a similar time course. The results suggest that hormonal feedback regulates opioid peptides which act at mu-receptors in the MPOA to influence reproductive behavior and cyclicity. These opioid functions represent an important component in the complex regulatory processes which control reproduction. (C) 1994 Academic Press, Inc.
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页码:431 / 437
页数:7
相关论文
共 27 条
[1]   ENDOGENOUS OPIOID-IMMUNOREACTIVE NEURONS OF THE VENTROMEDIAL HYPOTHALAMIC NUCLEUS CONCENTRATE ESTROGEN IN MALE AND FEMALE RATS [J].
AKESSON, TR ;
MICEVYCH, PE .
JOURNAL OF NEUROSCIENCE RESEARCH, 1991, 28 (03) :359-366
[2]   ENDOGENOUS OPIOIDS - BIOLOGY AND FUNCTION [J].
AKIL, H ;
WATSON, SJ ;
YOUNG, E ;
LEWIS, ME ;
KHACHATURIAN, H ;
WALKER, JM .
ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :223-255
[3]   INHIBITION OF SEXUAL-BEHAVIOR IN FEMALE RATS BY INTRACEREBRAL INJECTIONS OF MET-ENKEPHALIN IN COMBINATION WITH AN INHIBITOR OF ENKEPHALIN DEGRADING ENZYMES [J].
BEDNAR, I ;
FORSBERG, G ;
SODERSTEN, P .
NEUROSCIENCE LETTERS, 1987, 79 (03) :341-345
[4]  
BOHLER HCL, 1991, ENDOCRINOLOGY, V129, P1265
[5]  
CHEUNG S, 1994, FASEB J, V8, pA111
[6]  
CHEUNG S, 1994, IN PRESS BRAIN RES
[7]   CLONING OF A DELTA OPIOID RECEPTOR BY FUNCTIONAL EXPRESSION [J].
EVANS, CJ ;
KEITH, DE ;
MORRISON, H ;
MAGENDZO, K ;
EDWARDS, RH .
SCIENCE, 1992, 258 (5090) :1952-1955
[8]   ENDOGENOUS OPIOID-PEPTIDES AND THE MENSTRUAL-CYCLE [J].
FERIN, M .
TRENDS IN NEUROSCIENCES, 1984, 7 (06) :194-196
[9]  
GE F, 1992, NEUROENDOCRINOLOGY, V11, P101