Biology of membrane transport proteins

被引：40

作者：

Sadee, W ^{[1
]}

Drubbisch, V ^{[1
]}

Amidon, GL ^{[1
]}

机构：

[1] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI USA

来源：

PHARMACEUTICAL RESEARCH | 1995年 / 12卷 / 12期

关键词：

membrane transporters; glucose; peptides; multidrug resistance; transporter regulation; transporter gene families; genetic transporter defects;

D O I：

10.1023/A:1016211015926

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Membrane transporter proteins are encoded by numerous genes that can be classified into several superfamilies, on the basis of sequence identity and biological function. Prominent examples include facilitative transporters, the secondary active symporters and antiporters driven by ion gradients, and active ABC (ATP binding cassette) transporters involved in multiple-drug resistance and targeting of antigenic peptides to MHC Class I molecules. Transported substrates range from nutrients and ions to a broad variety of drugs, peptides and proteins. Deleterious mutations of transporter genes may lead to genetic diseases or loss of cell viability, Transporter structure, function and regulation, genetic factors, and pharmaceutical implications are summarized in this review.

引用

页码：1823 / 1837

页数：15

共 105 条

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