APPLICATION OF PHARMACOKINETIC PRINCIPLES IN EXTRAPOLATION OF ANIMAL DATA TO HUMANS

被引：13

作者：

GILLETTE, JR ^{[1
]}

机构：

[1] NHLI,CHEM PHARMACOL LAB,BETHESDA,MD 20014

来源：

CLINICAL TOXICOLOGY | 1976年 / 9卷 / 05期

关键词：

D O I：

10.3109/15563657608988176

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

引用

页码：709 / 722

页数：14

共 19 条

[1] STUDIES IN DETOXICATION .51. THE DETERMINATION OF CATECHOLS IN URINE, AND THE FORMATION OF CATECHOLS IN RABBITS RECEIVING HALOGENOBENZENES AND OTHER COMPOUNDS - DIHYDROXYLATION INVIVO [J].

AZOUZ, WM ;

PARKE, DV ;

WILLIAMS, RT .

BIOCHEMICAL JOURNAL, 1953, 55 (01) :146-151

[2]

Bauman E., 1879, BERICHTE DTSCH GESSE, V12, P806

[3] POSSIBLE MECHANISM OF LIVER NECROSIS CAUSED BY AROMATIC ORGANIC COMPOUNDS [J].

BRODIE, BB ;

REID, WD ;

CHO, AK ;

SIPES, G ;

KRISHNA, G ;

GILLETTE, JR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (01) :160-&

[4]

DALY JW, 1972, EXPERIENTIA, V28, P1129, DOI 10.1007/BF01946135

[5] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J].

GILLETTE, JR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) :2785-2794

[6]

GILLETTE JR, 1965, ANN NY ACAD SCI, V123, P42

[7] BIOCHEMICAL MECHANISMS OF DRUG TOXICITY [J].

GILLETTE, JR ;

MITCHELL, JR ;

BRODIE, BB .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1974, 14 :271-288

[8] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .2. ALTERATIONS IN KINETICS OF COVALENT BINDING [J].

GILLETTE, JR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (21) :2927-2938

[9]

GILLETTE JR, 1973, 5 P INT C PHARM SAN, V2, P187

[10] ACETAMINOPHEN-INDUCED HEPATIC NECROSIS .6. METABOLIC DISPOSITION OF TOXIC AND NONTOXIC DOSES OF ACETAMINOPHEN [J].

JOLLOW, DJ ;

THORGEIRSSON, SS ;

POTTER, WZ ;

HASHIMOTO, M ;

MITCHELL, JR .

PHARMACOLOGY, 1974, 12 (4-5) :251-271

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