N-METHYL-D-ASPARTATE ANTAGONIST REDUCES STROKE SIZE AND REGIONAL GLUCOSE-METABOLISM

被引：152

作者：

SIMON, R

SHIRAISHI, K

机构：

[1] Department of Neurology, University of California, San Francisco, San Francisco, California

来源：

ANNALS OF NEUROLOGY | 1990年 / 27卷 / 06期

关键词：

D O I：

10.1002/ana.410270604

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pharmacological inhibition of cell excitation during focal ischemia was studied in the rat middle cerebral artery occlusion model. The potent and selective N‐methyl‐D‐aspartate antagonist CGS 19755, administered 5 minutes prior to or 5 minutes following permanent middle cerebral artery occlusion, caused a substantial decrease in infarct size, which was associated with reduction of postischemic cerebral glucose hypermetabolism. These data support a role for excitation‐induced hypermetabolism in the pathogenesis of infarction following focal cerebrovascular occlusion. Copyright © 1990 American Neurological Association

引用

页码：606 / 611

页数：6

共 26 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].