EMERGING APPLICATIONS OF THE METHYLOTROPHIC YEASTS

被引：43

作者：

WEGNER, GH

机构：

[1] Research and Development, Phillips Petroleum Company, Bartlesville, OK

来源：

FEMS MICROBIOLOGY LETTERS | 1990年 / 87卷 / 3-4期

关键词：

PICHIA-PASTORIS; EXPRESSION SYSTEMS; ALCOHOL OXIDASE;

D O I：

10.1016/0378-1097(90)90467-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of methylotrophic yeasts for the production of single-cell-protein (SCP), alcohol oxidase and fine chemicals has been proposed. Fermentation technology developed for the growth of these yeasts on methanol at high cell densities has been commercialized. However, it is the production of heterologous recombinant proteins by Pichia pastoris that is emerging as the most significant application of the methylotrophic yeasts.

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页码：279 / 283

页数：5

相关论文

共 22 条

[1] PICHIA-PASTORIS AS A HOST SYSTEM FOR TRANSFORMATIONS [J].

CREGG, JM ;

BARRINGER, KJ ;

HESSLER, AY ;

MADDEN, KR .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (12) :3376-3385

[2] HIGH-LEVEL EXPRESSION AND EFFICIENT ASSEMBLY OF HEPATITIS-B SURFACE-ANTIGEN IN THE METHYLOTROPHIC YEAST, PICHIA-PASTORIS [J].

CREGG, JM ;

TSCHOPP, JF ;

STILLMAN, C ;

SIEGEL, R ;

AKONG, M ;

CRAIG, WS ;

BUCKHOLZ, RG ;

MADDEN, KR ;

KELLARIS, PA ;

DAVIS, GR ;

SMILEY, BL ;

CRUZE, J ;

TORREGROSSA, R ;

VELICELEBI, G ;

THILL, GP .

BIO-TECHNOLOGY, 1987, 5 (05) :479-485

[3] ENZYMATIC BASIS FOR OVERPRODUCTION OF TRYPTOPHAN AND ITS METABOLITES IN HANSENULA-POLYMORPHA MUTANTS [J].

DENENU, EO ;

DEMAIN, AL .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1981, 42 (03) :497-501

[4] CONTINUOUS PRODUCTION OF A NOVEL LYSOZYME VIA SECRETION FROM THE YEAST, PICHIA-PASTORIS [J].

DIGAN, ME ;

LAIR, SV ;

BRIERLEY, RA ;

SIEGEL, RS ;

WILLIAMS, ME ;

ELLIS, SB ;

KELLARIS, PA ;

PROVOW, SA ;

CRAIG, WS ;

VELICELEBI, G ;

HARPOLD, MM ;

THILL, GP .

BIO-TECHNOLOGY, 1989, 7 (02) :160-164

[5] OXIDATION OF BENZYL ALCOHOL BY WHOLE CELLS OF PICHIA-PASTORIS AND BY ALCOHOL OXIDASE IN AQUEOUS AND NONAQUEOUS REACTION MEDIA [J].

DUFF, SJB ;

MURRAY, WD .

BIOTECHNOLOGY AND BIOENGINEERING, 1989, 34 (02) :153-159

[6] ISOLATION OF ALCOHOL OXIDASE AND 2 OTHER METHANOL REGULATABLE GENES FROM THE YEAST PICHIA-PASTORIS [J].

ELLIS, SB ;

BRUST, PF ;

KOUTZ, PJ ;

WATERS, AF ;

HARPOLD, MM ;

GINGERAS, TR .

MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (05) :1111-1121

[7] SIZE DISTRIBUTION AND GENERAL STRUCTURAL FEATURES OF N-LINKED OLIGOSACCHARIDES FROM THE METHYLOTROPHIC YEAST, PICHIA-PASTORIS [J].

GRINNA, LS ;

TSCHOPP, JF .

YEAST, 1989, 5 (02) :107-115

[8]

HAGENSON MJS, 1990, PURIFICATION ANAL RE, P193

[9] METHANOL ASSIMILATION BY YEASTS [J].

HAZEU, W ;

BOS, P ;

DEBRUYN, JC .

ARCHIV FUR MIKROBIOLOGIE, 1972, 87 (02) :185-&

[10]

KATO N, 1986, APPL MICROBIOL BIOT, V23, P180