INTERACTION OF THE MALONYLDIALDEHYDE MOLECULE WITH MEMBRANES - A DIFFERENTIAL SCANNING CALORIMETRY, H-1-NMR, P-31-NMR AND ESR STUDY

被引：17

作者：

DEBOUZY, JC ^{[1
]}

FAUVELLE, F ^{[1
]}

VEZIN, H ^{[1
]}

BRASME, B ^{[1
]}

CHANCERELLE, Y ^{[1
]}

机构：

[1] CRSSA,UNITE RADIOBIOCHIM,F-38700 LA TRONCHE,FRANCE

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 09期

关键词：

D O I：

10.1016/0006-2952(92)90073-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The membrane interactions of malonyldialdehyde (MDA), natural product of polyunsaturated fatty acids peroxidation were investigated by differential scanning calorimetry, and ESR or NMR spectroscopy. This component is located in the superficial part of the bilayer, where it increases the local fluidity. High concentrations of MDA induce major membrane damage. Similar consequences of MDA-membrane interactions were observed on erythrocyte ghosts.

引用

页码：1787 / 1793

页数：7

共 26 条

[1] UNEQUIVOCAL DEMONSTRATION THAT MALONDIALDEHYDE IS A MUTAGEN
BASU, AK
MARNETT, LJ
[J]. CARCINOGENESIS, 1983, 4 (03) : 331 - 333
[2] CHEMISTRY UNDER PHYSIOLOGICAL CONDITIONS .8. NMR-SPECTROSCOPY OF MALONDIALDEHYDE
BERTZ, SH
DABBAGH, G
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (17) : 5161 - 5165
[3] NUCLEAR RELAXATION STUDIES OF LECITHIN BILAYERS
CHAN, SI
FEIGENSON, GW
SEITER, CHA
[J]. NATURE, 1971, 231 (5298) : 110 - +
[4] THIOBARBITURIC ACID REACTION AND AUTOXIDATIONS OF POLYUNSATURATED FATTY ACID METHYL ESTERS
DAHLE, LK
HILL, EG
HOLMAN, RT
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1962, 98 (02) : 253 - &
[5] UNUSUAL PHASE PROPERTIES OF DILAURYL PHOSPHATIDYLCHOLINE (C12PC)
FINEGOLD, L
SHAW, WA
SINGER, MA
[J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1990, 53 (2-3) : 177 - 184
[6] STUDIES OF THE MAILLARD REACTION .1. REACTION OF AMINO-SUGARS WITH MALONDIALDEHYDE
GOMEZSANCHEZ, A
MAYA, I
HERMOSIN, I
[J]. CARBOHYDRATE RESEARCH, 1990, 200 : 167 - 180
[7] GORENSTEIN DG, 1974, PHOSPHORUS 31 NMR PR
[8] RADIATION-INDUCED LIPID-PEROXIDATION AND THE FLUIDITY OF ERYTHROCYTE-MEMBRANE LIPIDS
GUILLE, J
RAISON, JK
GEBICKI, JM
[J]. FREE RADICAL BIOLOGY AND MEDICINE, 1987, 3 (02) : 147 - 152
[9] MEMBRANE PROPERTIES OF SATURATED FATTY-ACID MUTANTS OF YEAST REVEALED BY SPIN LABELS
HENRY, SA
KEITH, AD
[J]. CHEMISTRY AND PHYSICS OF LIPIDS, 1971, 7 (04) : 245 - +
[10] HERBETTE L, 1983, MOL PHARMACOL, V24, P259

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