MICROGLIA ARE ASSOCIATED WITH THE EXTRACELLULAR NEUROFIBRILLARY TANGLES OF ALZHEIMER-DISEASE

被引：83

作者：

CRAS, P

KAWAI, M

SIEDLAK, S

PERRY, G

机构：

[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland

来源：

BRAIN RESEARCH | 1991年 / 558卷 / 02期

关键词：

AMYLOID PRECURSOR PROTEIN; RICINUS-COMMUNIS AGGLUTININ; SENILE PLAQUE; PAIRED HELICAL FILAMENT; CYTOSKELETON;

D O I：

10.1016/0006-8993(91)90783-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

When neurons die, the filaments of neurofibrillary tangles (NFT) undergo structural and antigenic modifications. The exact mechanism of this modification is unknown, but glial cells could play an important role. Previous studies have shown that astroglial processes infiltrate extracellular NFT. In this study we use double immunolabelling to show that microglia also infiltrate extracellular NFT. Therefore, along with the previously identified astroglia, the microglia could be responsible for the modification of extracellular NFT.

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页码：312 / 314

页数：3

相关论文

共 14 条

[1]

BONDAREFF W, 1990, AM J PATHOL, V137, P711

[2]

Dolman C. L., 1985, TXB NEUROPATHOLOGY, P117

[3] DIAGNOSIS OF ALZHEIMERS-DISEASE [J].

KHACHATURIAN, ZS .

ARCHIVES OF NEUROLOGY, 1985, 42 (11) :1097-1104

[4] A68 - A MAJOR SUBUNIT OF PAIRED HELICAL FILAMENTS AND DERIVATIZED FORMS OF NORMAL-TAU [J].

LEE, VMY ;

BALIN, BJ ;

OTVOS, L ;

TROJANOWSKI, JQ .

SCIENCE, 1991, 251 (4994) :675-678

[5] A SPECIFIC HISTOCHEMICAL MARKER (LECTIN RICINUS-COMMUNIS AGGLUTININ-1) FOR NORMAL HUMAN MICROGLIA, AND APPLICATION TO ROUTINE HISTOPATHOLOGY [J].

MANNOJI, H ;

YEGER, H ;

BECKER, LE .

ACTA NEUROPATHOLOGICA, 1986, 71 (3-4) :341-343

[6]

OKAMOTO K, 1982, CLIN NEUROL, V22, P840

[7] NEUROFIBRILLARY TANGLES, NEUROPIL THREADS AND SENILE PLAQUES ALL CONTAIN ABUNDANT BINDING-SITES FOR BASIC FIBROBLAST GROWTH-FACTOR (B-FGF) [J].

PERRY, G ;

SIEDLAK, S ;

KAWAI, M ;

CRAS, P ;

MULVIHILL, P ;

CORDELL, B ;

SCARDINA, JM ;

GAMBETTI, P .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1990, 49 (03) :318-318

[8] SENILE DEMENTIA OF ALZHEIMER TYPE - ASTROGLIAL REACTION TO EXTRACELLULAR NEUROFIBRILLARY TANGLES IN THE HIPPOCAMPUS - AN IMMUNO-CYTOCHEMICAL AND ELECTRON-MICROSCOPIC STUDY [J].

PROBST, A ;

ULRICH, J ;

HEITZ, PU .

ACTA NEUROPATHOLOGICA, 1982, 57 (01) :75-79

[9] A4-PROTEIN IN ALZHEIMERS-DISEASE - PRIMARY AND SECONDARY CELLULAR EVENTS IN EXTRACELLULAR AMYLOID DEPOSITION [J].

ROZEMULLER, JM ;

EIKELENBOOM, P ;

STAM, FC ;

BEYREUTHER, K ;

MASTERS, CL .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1989, 48 (06) :674-691

[10] INTRANEURONAL AND EXTRACELLULAR NEUROFIBRILLARY TANGLES EXHIBIT MUTUALLY EXCLUSIVE CYTOSKELETAL ANTIGENS [J].

SCHMIDT, ML ;

GUR, RE ;

GUR, RC ;

TROJANOWSKI, JQ .

ANNALS OF NEUROLOGY, 1988, 23 (02) :184-189