L-745,337 - A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 ELICITS ANTINOCICEPTION BUT NOT GASTRIC-ULCERATION IN RATS

被引：64

作者：

BOYCE, S ^{[1
]}

CHAN, CC ^{[1
]}

GORDON, R ^{[1
]}

LI, CS ^{[1
]}

RODGER, IW ^{[1
]}

WEBB, JK ^{[1
]}

RUPNIAK, NMJ ^{[1
]}

HILL, RG ^{[1
]}

机构：

[1] MERCK FROSST CTR THERAPEUT RES, KIRKLAND, PQ, CANADA

来源：

NEUROPHARMACOLOGY | 1994年 / 33卷 / 12期

关键词：

NSAIDS; COX-2; ANALGESIA;

D O I：

10.1016/0028-3908(94)90137-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

L-745,337 [5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indanone] a selective cycleoxygenase-2 inhibitor reversed hyperalgesia induced by carrageenan in rats without causing gastric ulceration at doses 100 times those causing antinociception. In contrast, piroxicam and indomethacin produced ulcerations at antinociceptive doses. These findings demonstrate that L-745,337 possesses antinociceptive activity but has a reduced liability for gastric ulceration.

引用

页码：1609 / 1611

页数：3

共 9 条

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