ENHANCED PRESSER RESPONSE TO ANGIOTENSIN-III IN SPONTANEOUSLY HYPERTENSIVE RATS - EFFECTS OF LOSARTAN

被引：7

作者：

RADHAKRISHNAN, R ^{[1
]}

SIM, MK ^{[1
]}

机构：

[1] NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL,SINGAPORE 0511,SINGAPORE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 01期

关键词：

ANGIOTENSIN II; ANGIOTENSIN III; SPONTANEOUSLY HYPERTENSIVE RAT (SHR); LOSARTAN; (DUP; 753); TELEMETRY;

D O I：

10.1016/0014-2999(94)90163-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The conscious spontaneously hypertensive rat (SHR), compared to its normotensive control Wistar Kyoto rat (WKY), exhibited a significantly greater presser response to i.v. angiotensin II and angiotensin III. Losartan (10 mg/kg i.v.) lowered the basal blood pressure of the SHR but had no significant effect on that of the WKY. However, it attenuated the presser response to both angiotensins in the SHR and WKY, the degree of attenuation being significantly greater with angiotensin III. In addition, the presser responses induced by both angiotensin II and angiotensin III in the WKY, compared to those of the SHR, were more markedly inhibited by losartan. The results indicate a possible over-expression of angiotensin AT(1) receptors in the SHR, and that both angiotensin II and angiotensin III contribute to the hypertension by acting on these receptors.

引用

页码：87 / 90

页数：4

共 8 条

[1] PROLONGED ANGIOTENSIN-II ANTAGONISM IN SPONTANEOUSLY HYPERTENSIVE RATS - HEMODYNAMIC AND BIOCHEMICAL CONSEQUENCES [J].

BUNKENBURG, B ;

SCHNELL, C ;

BAUM, HP ;

CUMIN, F ;

WOOD, JM .

HYPERTENSION, 1991, 18 (03) :278-288

[2]

DAMOUR FE, 1948, MANUAL LABORATORY WO

[3]

DELRIO CG, 1981, ENDOCRINOLOGY, V108, P406

[4] HYPERTENSION DURING CHRONIC PERIPHERAL AND CENTRAL INFUSION OF ANGIOTENSIN-III [J].

FINK, GD ;

BRUNER, CA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (02) :E201-E208

[5] DIFFERENTIAL PRESSOR AND RENAL VASCULAR REACTIVITY TO ANGIOTENSIN-II IN SPONTANEOUSLY HYPERTENSIVE AND WISTAR-KYOTO RATS [J].

GUIDI, E ;

HOLLENBERG, NK .

HYPERTENSION, 1987, 9 (06) :591-597

[6]

RADHAKRISHNAN R, 1993, ASIA PACIFIC J PHARM, V8, pS30

[7] ANGIOTENSIN-2 AND ANGIOTENSIN-3 IN RAT BLOOD [J].

SEMPLE, PF ;

MORTON, JJ .

CIRCULATION RESEARCH, 1976, 38 (06) :122-126

[8] HYPOTENSIVE ACTION OF DUP-753, AN ANGIOTENSIN-II ANTAGONIST, IN SPONTANEOUSLY HYPERTENSIVE RATS - NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS .10. [J].

WONG, PC ;

PRICE, WA ;

CHIU, AT ;

DUNCIA, JV ;

CARINI, DJ ;

WEXLER, RR ;

JOHNSON, AL ;

TIMMERMANS, PBMWM .

HYPERTENSION, 1990, 15 (05) :459-468

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