EFFECT OF CONAGENIN ON THROMBOCYTOPENIA INDUCED BY ANTITUMOR AGENTS IN MICE

被引:23
作者
KAWATSU, M [1 ]
YAMASHITA, T [1 ]
ISHIZUKA, M [1 ]
TAKEUCHI, T [1 ]
机构
[1] MCRF,INST CHEMOTHERAPY,SHIZUOKA 41003,JAPAN
关键词
D O I
10.7164/antibiotics.47.1123
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The effect of conagenin (CNG) on myelosuppression induced by antitumor agents was investigated. The daily administration of CNG prevented reduction in the number of platelets (PLT) observed in peripheral blood of mice given mitomycin C (10 mg/kg) but did not prevent reduction in the number of leukocytes (WBC). The effect on PLT was also confirmed in mice given cyclophosphamide (100 mg/kg). In mice given repeated doses of 5-fluorouracil (10 mg/kg), CNG prevented the reduction of PLT as well as WBC and maintained them at normal levels. CNG prevented reduction of the production of interleukin-2, 3 and 6 in cultured supernatants of spleen cells taken from mice given 5-fluorouracil. These results suggest that CNG modulates production of lymphokines which are responsible for thrombopoiesis.
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页码:1123 / 1129
页数:7
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