IMPLICATION OF NON-LINEAR KINETICS ON RISK-ESTIMATION IN CARCINOGENESIS

被引:149
作者
HOEL, DG [1 ]
KAPLAN, NL [1 ]
ANDERSON, MW [1 ]
机构
[1] NIEHS,PHARMACOL LAB,MOLEC & COMPARAT PHARMACOL SECT,RES TRIANGLE PK,NC 27709
关键词
D O I
10.1126/science.6823565
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:1032 / 1037
页数:6
相关论文
共 30 条
[1]  
ADRIAENSSENS PI, CANCER RES
[2]   A GENERAL SCHEME FOR THE INCORPORATION OF PHARMACOKINETICS IN LOW-DOSE RISK-ESTIMATION FOR CHEMICAL CARCINOGENESIS - EXAMPLE - VINYL-CHLORIDE [J].
ANDERSON, MW ;
HOEL, DG ;
KAPLAN, NL .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1980, 55 (01) :154-161
[3]  
ANDERSON MW, 1981, CANCER RES, V41, P4309
[4]   EVIDENCE FOR BINDING OF POLYNUCLEAR AROMATIC HYDRO-CARBONS TO NUCLEIC ACIDS OF MOUSE SKIN - RELATION BETWEEN CARCINOGENIC POWER OF HYDROCARBONS + THEIR BINDING TO DEOXYRIBONUCLEIC ACID [J].
BROOKES, P ;
LAWLEY, PD .
NATURE, 1964, 202 (493) :781-&
[5]  
BROWN KG, FUND APPL TOXICOL
[6]  
COHEN GM, 1979, CANCER RES, V39, P4027
[7]  
COLBURN NH, 1968, CANCER RES, V28, P653
[8]  
FAHL WE, 1981, CANCER RES, V41, P3400
[9]  
GEHRING PJ, 1977, J ENVIRON PATHOL TOX, V1, P163
[10]   RESOLUTION OF DOSE-RESPONSE TOXICITY DATA FOR CHEMICALS REQUIRING METABOLIC ACTIVATION - EXAMPLE VINYL CHLORIDE [J].
GEHRING, PJ ;
WATANABE, PG ;
PARK, CN .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 1978, 44 (03) :581-591