SEPARATION OF HI-6 [4-CARBAMOYL-2'-HYDROXYIMINOMETHYL-1,1'-OXYDIMETHYLEN-DI(PYRIDINIUM CHLORIDE)] AND ITS DEGRADATION PRODUCTS BY ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：11

作者：

BROWN, ND ^{[1
]}

STERMERCOX, MG ^{[1
]}

DOCTOR, BP ^{[1
]}

HAGEDORN, J ^{[1
]}

机构：

[1] UNIV FREIBURG,DEPT CHEM,D-7800 FREIBURG,FED REP GER

来源：

JOURNAL OF CHROMATOGRAPHY | 1984年 / 292卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(01)83626-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

引用

页码：444 / 450

页数：7

共 13 条

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BENSCHOP, HP ;

KONINGS, KAG ;

KOSSEN, SP ;

LIGTENSTEIN, DA .

JOURNAL OF CHROMATOGRAPHY, 1981, 225 (01) :107-114

[2]

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[3] DETERMINATION OF N-METHYL PYRIDINIUM-2-ALDOXIME CHLORIDE AND ITS HYDROLYTIC BY-PRODUCTS BY ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BROWN, ND ;

STRICKLER, MP ;

SLEEMAN, HK ;

DOCTOR, BP .

JOURNAL OF CHROMATOGRAPHY, 1981, 212 (03) :361-365

[4]

CHRISTEN.I, 1972, ACTA PHARM SUEC, V9, P323

[5] HI-6, AN OXIME WHICH IS AN EFFECTIVE ANTIDOTE OF SOMAN POISONING - A STRUCTURE-ACTIVITY STUDY [J].

CLEMENT, JG ;

LOCKWOOD, PA .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1982, 64 (01) :140-146

[6] HI-6 - REACTIVATION OF CENTRAL AND PERIPHERAL ACETYLCHOLINESTERASE FOLLOWING INHIBITION BY SOMAN, SARIN AND TABUN INVIVO IN THE RAT [J].

CLEMENT, JG .

BIOCHEMICAL PHARMACOLOGY, 1982, 31 (07) :1283-1287

[7] PASSAGE OF PYRIDINIUM OXIMES INTO HUMAN RED-CELLS [J].

ELLIN, RI ;

GROFF, WA ;

SIDELL, FR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (19) :2663-2670

[8]

HAGEDORN I, 1976, ARZNEIMITTEL-FORSCH, V26, P1273

[9]

HAGEDORN I, 1978, ARZNEIMITTEL-FORSCH, V28, P2055

[10]

KEPNER LA, 1978, EUR J PHARMACOL, V49, P415

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