EFFECTS OF L-MENTHOL AND DL-CAMPHOR ON THE PENETRATION AND HYDROLYSIS OF METHYL SALICYLATE IN HAIRLESS MOUSE SKIN

被引：26

作者：

YANO, T

KANETAKE, T

SAITA, M

NODA, K

机构：

[1] Research Laboratories, Hisamitsu Pharmaceutical Co., Inc., Tosu, Saga, 841

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1991年 / 14卷 / 12期

关键词：

HYDROLYSIS; METHYL SALICYLATE; L-MENTHOL; DL-CAMPHOR; MEDICATED PLASTER; SKIN PENETRATION; SKIN HOMOGENATE; HAIRLESS MOUSE;

D O I：

10.1248/bpb1978.14.663

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Plasters containing methyl salicylate with and without l-menthol and dl-camphor were prepared and topically applied on hairless mouse skin to investigate the effects of l-menthol and dl-camphor on the skin penetration and hydrolysis of methyl salicylate in the skin. The in vitro hydrolysis of methyl salicylate was also investigated using the skin homogenate. It was found that l-menthol with dl-camphor enhanced the skin penetration of methyl salicylate, and they inhibited both the in vivo and in vitro hydrolysis of methyl salicylate to salicylic acid.

引用

页码：663 / 669

页数：7

共 27 条

[1] ABSORPTION AND ESTER CLEAVAGE OF METHYL SALICYLATE BY SKIN OF SINGLE-PASS PERFUSED RABBIT EARS [J].