RECOVERY IN HEMIPARKINSONIAN RATS FOLLOWING INTRASTRIATAL IMPLANTATION OF ACTIVATED LEUKOCYTES

被引：30

作者：

EWING, SE

WEBER, RJ

ZAUNER, A

PLUNKETT, RJ

机构：

[1] NINCDS, SURG NEUROL BRANCH, BETHESDA, MD 20892 USA

[2] NIDDKD, MED CHEM LAB, NEUROIMMUNOL UNIT, BETHESDA, MD 20892 USA

来源：

BRAIN RESEARCH | 1992年 / 576卷 / 01期

基金：

美国国家卫生研究院;

关键词：

6-HYDROXYDOPAMINE; HEMIPARKINSONIAN RAT; ACTIVATED LEUKOCYTE; CENTRAL NERVOUS SYSTEM IMPLANTATION; FLUORESCENT ACTIVATED CELL SORTING;

D O I：

10.1016/0006-8993(92)90607-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Behavioral improvement has been seen in hemiparkinsonian animals after surgical lesions of the denervated caudate nucleus. This study was designed to investigate the role of inflammatory cells in injury-induced recovery. A hemiparkinsonian syndrome was induced in rats by unilateral injections of 6-hydroxydopamine into the pars compacta of the substantia nigra. Phytohemagglutinin-stimulated rat peritoneal cells, predominantly T cells and macrophages, were stereotactically implanted in the lesioned caudate-putamen, and amphetamine-induced turning was used to assess recovery. Animals receiving implants of activated peritoneal cells showed a 47% decrease in amphetamine-induced turning 8 weeks after implantation, which was not seen in control or sham-operated animals. Immunocytochemistry revealed increased tyrosine hydroxylase reactive fibers in the leukocyte-implanted striatum. We conclude that implantation of activated leukocytes promotes functional recovery in hemiparkinsonian rats.

引用

页码：42 / 48

页数：7

共 40 条

[1] ADAMS RD, 1985, PRINCIPLES NEUROLOGY, P807
[2] RAT ASTROCYTES AND SCHWANN-CELLS IN CULTURE SYNTHESIZE NERVE GROWTH FACTOR-LIKE NEURITE-PROMOTING FACTORS
ASSOULINE, JG
BOSCH, P
LIM, R
KIM, IS
JENSEN, R
PANTAZIS, NJ
[J]. DEVELOPMENTAL BRAIN RESEARCH, 1987, 31 (01): : 103 - 118
[3] BACKLUND EO, 1985, NEURAL GRAFTING MAMM, P551
[4] THE EFFECT OF FETAL MESENCEPHALON IMPLANTS ON PRIMATE MPTP-INDUCED PARKINSONISM - HISTOCHEMICAL AND BEHAVIORAL-STUDIES
BANKIEWICZ, KS
PLUNKETT, RJ
JACOBOWITZ, DM
PORRINO, L
DIPORZIO, U
LONDON, WT
KOPIN, IJ
OLDFIELD, EH
[J]. JOURNAL OF NEUROSURGERY, 1990, 72 (02) : 231 - 244
[5] BANKIEWICZ KS, 1986, LIFE SCI, V39, P7, DOI 10.1016/0024-3205(86)90431-5
[6] BANKIEWICZ KS, 1988, PROGR BRAIN RES, V78, P543
[7] Benveniste E N, 1988, Ann N Y Acad Sci, V540, P392, DOI 10.1111/j.1749-6632.1988.tb27111.x
[8] RESPONSE OF HUMAN GLIOBLASTOMA CELLS TO RECOMBINANT INTERLEUKIN-2
BENVENISTE, EN
TOZAWA, H
GASSON, JC
QUAN, S
GOLDE, DW
MERRILL, JE
[J]. JOURNAL OF NEUROIMMUNOLOGY, 1988, 17 (04) : 301 - 314
[9] STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2
BENVENISTE, EN
MERRILL, JE
[J]. NATURE, 1986, 321 (6070) : 610 - 613
[10] DUNNETT SB, 1987, J EXP BIOL, V132, P265

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