SELECTIVE AMINOACYLATION OF NUCLEOSIDES THROUGH AN ENZYMATIC-REACTION WITH OXIME AMINOACYL ESTERS

被引：17

作者：

MORIS, F ^{[1
]}

GOTOR, V ^{[1
]}

机构：

[1] UNIV OVIEDO,FAC QUIM,DEPT QUIM ORGAN & INORGAN,E-33071 OVIEDO,SPAIN

来源：

TETRAHEDRON | 1994年 / 50卷 / 23期

关键词：

NUCLEOSIDES; OXIME AMINOACYL ESTERS; ENZYMATIC AMINOACYLATION; REGIOSELECTIVITY;

D O I：

10.1016/S0040-4020(01)81345-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-protected aminoacyl acetoxime esters are useful agents for enzymatic aminoacylation of 2'-deoxy- and ribo-nucleosides. In both cases, 5'-O-derivatives can be prepared if the lipase used is SP 435 (from Candida antarctica) whereas 3'-O-isomers from 2'-deoxynucleosides are obtained with Pseudomonas cepacia.

引用

页码：6927 / 6934

页数：8

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