ISOLATION OF ALDOSE REDUCTASE INHIBITORS FROM THE FLOWERS OF CHRYSANTHEMUM-BOREALE

被引：35

作者：

SHIN, KH

KANG, SS

SEO, EA

SHIN, SW

机构：

[1] SEOUL NATL UNIV,INST NAT PROD RES,SEOUL 110460,SOUTH KOREA

[2] DUK SUNG WOMENS UNIV,COLL PHARM,SEOUL 132070,SOUTH KOREA

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1995年 / 18卷 / 02期

关键词：

CHRYSANTHEMUM BOREALE; ALDOSE REDUCTASE INHIBITION; FLAVONOIDS; LUTEOLIN; ACACETIN; APIGENIN;

D O I：

10.1007/BF02979135

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanol extract from the whole parts of the flowers of Chrysanthemum boreale was found to exhibit a significant inhibition of rat lens aldose reductase (RLAR) activity in vitro. Bioassay guided systematic fractionation of the methanol extract led to the isolation of four flavonoids which were identified as acacetin (I), apigenin (II), luteolin (III) and linarin (IV). Compounds I-III were demonstrated to exhibit a significant inhibition of RLAR. Luteolin (III) was found to be the most potent AR inhibitor with IC50 value of 5x10(-7)M.

引用

页码：65 / 68

页数：4

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