SEPARATION OF ORGANOPHOSPHONATES BY ION CHROMATOGRAPHY WITH INDIRECT PHOTOMETRIC DETECTION

被引：23

作者：

THOMPSON, R

GRINBERG, N

PERPALL, H

BICKER, G

TWAY, P

机构：

[1] Merck Research Laboratories R80Y-115, Rahway, New Jersey, 07065-0914

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 11期

关键词：

D O I：

10.1080/10826079408013497

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

An ion chromatographic method which utilizes lithium trimesate to separate three diphosphonate drugs and two process related organophosphonates is described. The lack of a chromophore on the five species and the high absorptivity of the trimesate anion at 254 nm allows for facile detection using indirect photometry. The effects of mobile phase concentration on the capacity factor of the species were investigated and a logarithmic relationship was established which was found to be dependent on the charge of the analyte anion and the mobile phase anion.

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页码：2511 / 2531

页数：21

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