Antitumor and cytotoxic investigation of Amoora rohituka

被引：19

作者：

Rabi, T

Gupta, RC

机构：

[1] BANARAS HINDU UNIV,INST MED SCI,DEPT SHALYA SHALAKYA,VARANASI 221005,UTTAR PRADESH,INDIA

[2] BANARAS HINDU UNIV,INST MED SCI,CTR EXPT MED & SURG,VARANASI 221005,UTTAR PRADESH,INDIA

来源：

INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1995年 / 33卷 / 04期

关键词：

ethyl acetate extract; antitumor activity; Dalton's lymphoma ascites cells; Hep-2-cells;

D O I：

10.3109/13880209509065396

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

An ethyl acetate extract derived from the stem bark of Amoora rohituka exhibited antitumor activity on mice inoculated with Dalton's lymphoma ascites cells (DLA). Intraperitoneal administration of the extract at doses of 10 or 20 mg/kg/day prolonged the median survival time of the animals. It showed cytotoxicity against Dalton's lymphoma ascites cells with a 50% inhibitory concentration (IC50) of 9 mu g/ml, with no activity against Hep-2 cells from a tumor of the larynx.

引用

页码：359 / 361

页数：3