DETERMINATION OF SULFONAMIDES OF PHARMACEUTICAL IMPORTANCE BY CATALYTIC THERMOMETRIC TITRATION

被引：18

作者：

GREENHOW, EJ ^{[1
]}

SPENCER, LE ^{[1
]}

机构：

[1] UNIV LONDON,DEPT CHEM,LONDON SW3 6LX,ENGLAND

来源：

ANALYTICAL CHEMISTRY | 1975年 / 47卷 / 08期

关键词：

D O I：

10.1021/ac60358a035

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Tetra-n-butylammonium hydroxide, sodium methoxide, potassium methoxide, and potassium hydroxide, in nonaqueous solution, and pyridine, dimethylformamide dimethylsulfoxide, 1,1,3,3-tetramethylurea, and N,N,N prime ,N prime -tetramethyl-1,2-diaminoethane, have been evaluated as titrants and sample solvents, respectively, in the determination of the acidic functions of sulfanilamide derivatives and sulfonamide formulations. Satisfactory assay values are obtained with potassium hydroxide in propan-2-ol as the titrant, acrylonitrile as the solvent for sulfanilamide, dimethylsulfoxide as the solvent for sulfaguanidine, and dimethylformamide or dimethylsulfoxide as the solvent for other sulfonamides.

引用

页码：1384 / 1388

页数：5

共 18 条

[1]

[Anonymous], 1973, BRIT PHARMACOPEIA

[2] THERMOMETRIC ASSAY OF SOME SULFONAMIDES OF PHARMACEUTICAL IMPORTANCE [J].