THE INFLUENCE OF GENES MAPPING WITHIN THE MAJOR HISTOCOMPATIBILITY COMPLEX ON RESISTANCE TO TRICHURIS-MURIS INFECTIONS IN MICE

被引：70

作者：

ELSE, KJ

WAKELIN, D

WASSOM, DL

HAUDA, KM

机构：

[1] UNIV NOTTINGHAM, DEPT ZOOL, MRC, EXPTL PARASITOL UNIT, UNIV PK, NOTTINGHAM NG7 2RD, ENGLAND

[2] UNIV WISCONSIN, SCH VET MED, DEPT PATHOBIOL SCI, MADISON, WI 53706 USA

来源：

PARASITOLOGY | 1990年 / 101卷

基金：

英国医学研究理事会;

关键词：

genetic control; H-2; recombinant; major histocompatibility complex; resistance; Trichuris muris;

D O I：

10.1017/S0031182000079762

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Two panels of H-2 recombinant strains of mice were used in an attempt to map the H-2-Iinked genes which control resistance to infection with Trichuris muris. Response phenotypes could be related to the presence of ‘resistance’ (q, b) or ‘susceptibility’ (k, d) alleles at I-A. The influence of these genes was modulated by other alleles, particularly q or d alleles, at the D end of the H-2. Absence of I-E molecules correlated with resistance to infection in some but not all strains studied. Thus the (B10. BR x B10.G) Fl strain which expressed I-Ek gene products was resistant to infection. A study of the time-course of infection in strains of mice expressing q alleles throughout the H-2 on 4 different genetic backgrounds (NIH SWR, DBA and B10) revealed that most strains were resistant to infection. However, the DBA/1 strain exhibited differential responsiveness, 4 out of 6 individuals harbouring mature adult parasites on day 35 post-infection. © 1990, Cambridge University Press. All rights reserved.

引用

页码：61 / 67

页数：7

共 23 条

[1] A NOVEL TYPE OF T-T-CELL INTERACTION REMOVES THE REQUIREMENT FOR I-B REGION IN THE H-2-COMPLEX [J].

BAXEVANIS, CN ;

NAGY, ZA ;

KLEIN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (06) :3809-3813

[2] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN [J].

BEUTLER, B ;

CERAMI, A .

NATURE, 1986, 320 (6063) :584-588

[3]

Blackwell J. M., 1988, Genetics of resistance to bacterial and parasitic infection., P103

[4] IMMUNOMODULATION OF MURINE VISCERAL LEISHMANIASIS BY ADMINISTRATION OF MONOCLONAL ANTI-IA ANTIBODIES - DIFFERENTIAL-EFFECTS OF ANTI-I-A VS ANTI-I-E ANTIBODIES [J].

BLACKWELL, JM ;

ROBERTS, MB .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (11) :1669-1672

[5] A FUNCTIONAL DICHOTOMY IN CD4+ LYMPHOCYTES-T [J].

BOTTOMLY, K .

IMMUNOLOGY TODAY, 1988, 9 (09) :268-274

[6] THE EFFECTS OF H-2 AND NON-H-2 GENES ON THE EXPULSION OF THE NEMATODE TRICHURIS-MURIS FROM INBRED AND CONGENIC MICE [J].

ELSE, K ;

WAKELIN, D .

PARASITOLOGY, 1988, 96 :543-550

[7] HOST PREDISPOSITION TO TRICHURIASIS - THE MOUSE - TRICHURIS-MURIS MODEL [J].

ELSE, KJ ;

WAKELIN, D ;

ROACH, TIA .

PARASITOLOGY, 1989, 98 :275-282

[8] NEMATOSPIROIDES-DUBIUS - GENETIC-CONTROL OF IMMUNITY TO INFECTIONS OF MICE [J].

ENRIQUEZ, FJ ;

ZIDIAN, JL ;

CYPESS, RH .

EXPERIMENTAL PARASITOLOGY, 1988, 67 (01) :12-19

[9] NEMATOSPIROIDES-DUBIUS - 2 H-2-LINKED GENES INFLUENCE LEVELS OF RESISTANCE TO INFECTION IN MICE [J].

ENRIQUEZ, FJ ;

BROOKS, BO ;

CYPESS, RH ;

DAVID, CS ;

WASSOM, DL .

EXPERIMENTAL PARASITOLOGY, 1988, 67 (02) :221-226

[10] IMMUNOLOGICAL SELF, NONSELF DISCRIMINATION [J].

GUILLET, JG ;

LAI, MZ ;

BRINER, TJ ;

BUUS, S ;

SETTE, A ;

GREY, HM ;

SMITH, JA ;

GEFTER, ML .

SCIENCE, 1987, 235 (4791) :865-870

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