IS HYPERTENSION A MAJOR INDEPENDENT RISK FACTOR FOR RETINOPATHY IN TYPE-1 DIABETES

被引：45

作者：

NORGAARD, K

FELDTRASMUSSEN, B

DECKERT, T

机构：

[1] Steno Memorial Hospital, Gentofte

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 04期

关键词：

TYPE-1; DIABETES; RETINOPATHY; HYPERTENSION; NEPHROPATHY;

D O I：

10.1111/j.1464-5491.1991.tb01606.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hypertension is an established risk factor for retinopathy. Whether it is an independent risk factor or acts only by association with nephropathy is not known. Therefore, we studied 273 Type 1 diabetic patients. They were divided into four groups. Group 1 (n = 55) were normotensive and normoalbuminuric, group 2 (n = 51) had hypertension but were normoalbuminuris, group 3 (n = 33) had nepropathy but were normotensive, and group 4 (n = 134) had nephropathy and hypertension. Hypertensive patients with normoalbuminuria (blood pressure 146 +/- 19 (+/- SD)/87 +/- 12 mmHg) had the same prevalence of retinopathy as normoalbuminuric normotensive patients (123 +/- 12/75 +/- 5 mmHg). Hypertensive nephropathic patients (blood pressure 147 +/- 18/87 +/- 8 mmHg) had more retinopathy than hypertensive normoalbuminuric patients despite similar blood pressure (normal retina/advanced retinopathy: 3 %/73 % vs 46 %/17 %, p < 0.001). Nephropathic normotensive patients had worse retinal changes than hypertensive normoalbuminuric patients (19 %/49 %, p < 0.001) but fewer than the nephropathic hypertensive patients p < 0.001). Thus hypertension per se is not associated with increased retinal changes but may aggravate these in patients with clinical nephropathy.

引用

页码：334 / 337

页数：4

共 17 条

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