CLONING OF A MURINE IL-11 RECEPTOR ALPHA-CHAIN - REQUIREMENT FOR GP130 FOR HIGH-AFFINITY BINDING AND SIGNAL-TRANSDUCTION

被引:247
作者
HILTON, DJ
HILTON, AA
RAICEVIC, A
RAKAR, S
HARRISONSMITH, M
GOUGH, NM
BEGLEY, CG
METCALF, D
NICOLA, NA
WILLSON, TA
机构
[1] COOPERAT RES CTR CELLULAR GROWTH FACTORS,PARKVILLE,VIC,AUSTRALIA
[2] KIPSY,WARRANDYTE,VIC,AUSTRALIA
[3] ROYAL MELBOURNE HOSP,DEPT DIAGNOST HAEMATOL,PARKVILLE,VIC,AUSTRALIA
关键词
CYTOKINE RECEPTOR; INTERLEUKIN-11; RECEPTOR;
D O I
10.1002/j.1460-2075.1994.tb06802.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
An adult mouse liver cDNA library was screened with oligonucleotides corresponding to the conserved WSXWS motif of the haemopoietin receptor family. Using this method, cDNA clones encoding a novel receptor were isolated. The new receptor, named NR1, was most similar in sequence and predicted structure to the a-chain of the IL-6 receptor and mRNA was expressed in the 3T3-L1 pre-adipocytic cell line and in a range of primary tissues. Expression of NR1 in the factor-dependent haemopoietic cell line Ba/F3 resulted in the generation of low affinity receptors for IL-11 (K-d approximate to 10 nM). The capacity to bind IL-11 with high affinity (K-d = 300-800 pM) appeared to require coexpression of both NR1 and gp130, the common subunit of the IL-6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) receptors. The expression of both NR1 and gp130 was also necessary for Ba/F3 cells to proliferate and M1 cells to undergo macrophage differentiation in response to IL-11.
引用
收藏
页码:4765 / 4775
页数:11
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