HYPOTHALAMIC LINKAGE IN STRESS-INDUCED HYPOCALCEMIA, GASTRIC DAMAGE, AND EMOTIONAL BEHAVIOR IN RATS

被引：7

作者：

AOU, SJ ^{[1
]}

MA, JY ^{[1
]}

HORI, T ^{[1
]}

TASHIRO, N ^{[1
]}

机构：

[1] KYUSHU UNIV 60, FAC MED, DEPT NEUROPSYCHIAT, FUKUOKA 812, JAPAN

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1994年 / 267卷 / 01期

关键词：

HYPOTHALAMUS; ELECTROLYTIC LESION; GASTRIC ULCER; STRESS;

D O I：

10.1152/ajpregu.1994.267.1.R38

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The effects of hypothalamic lesions on stress induced hypocalcemia, gastric damage, and swim test-evoked behavior were examined in rats. Bilateral lesions of the ventromedial nucleus in the hypothalamus (VMH) eliminated water-restraint stress-induced hypocalcemia and attenuated any gastric damage compared with those in the sham-operated rats. In contrast, lesions in the paraventricular nucleus (PVN) exacerbated both the stress-induced hypocalcemia and gastric lesions in comparison with those in the control rats. In a forced-swimming test, the VMH-lesioned rats showed a significantly shorter time of immobility as well as a longer duration of struggling than the control rats, respectively, while the PVN-lesioned animals spent a longer time in immobility and a shorter period struggling than the control rats. These results suggest that the VMH has an accelerative action in stress-induced hypocalcemia, gastric lesions, and behavioral despair, while the PVN has an opposite effect.

引用

页码：R38 / R43

页数：6

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