Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment

被引：263

作者：

Sato, Yusuke ^{[1
]}

Goto, Yasufumi ^{[1
]}

Narita, Norihiko ^{[1
]}

Hoon, Dave S. B. ^{[1
]}

机构：

[1] St Johns Hlth Ctr, John Wayne Canc Inst, Dept Mol Oncol, 2200 Santa Monica Blvd, Santa Monica, CA 90404 USA

来源：

CANCER MICROENVIRONMENT | 2009年 / 2卷

关键词：

Toll-like receptor; Tumor microenvironment; DAMPs; PAMPs;

D O I：

10.1007/s12307-009-0022-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Toll-like receptors (TLRs) play a crucial role in the innate immune response and the subsequent induction of adaptive immune responses against microbial infection or tissue injury. Recent findings show that functional TLRs are expressed not only on immune cells but also on cancer cells. TLRs play an active role in carcinogenesis and tumor progression during chronic inflammation that involves the tumor microenvironment. Damage-associated molecular patterns (DAMPs) derived from injured normal epithelial cells and necrotic cancer cells appear to be present at significant levels in the tumor microenvironment, and their stimulation of specific TLRs can foster chronic inflammation. This review discusses how carcinogenesis, cancer progression, and site-specific metastasis are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment.

引用

页码：S205 / S214

页数：10