LOCAL PREVENTION OF THROMBOSIS IN ANIMAL ARTERIES BY MEANS OF MAGNETIC TARGETING OF ASPIRIN-LOADED RED-CELLS

被引：39

作者：

OREKHOVA, NM

AKCHURIN, RS

BELYAEV, AA

SMIRNOV, MD

RAGIMOV, SE

OREKHOV, AN

机构：

[1] Institute of Experimental Cardiology, USSR Cardiology Research Center, Academy of Medical Sciences, Moscow, 3rd Cherepkovskaya str. 15A

来源：

THROMBOSIS RESEARCH | 1990年 / 57卷 / 04期

关键词：

aspirin; magnetic transport; thrombosis;

D O I：

10.1016/0049-3848(90)90078-Q

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Trombosis was induced in I8 dog and I6 rabbit arteries by surgically inverting a vascular wall flap into its lumen. A completely occluding red thrombus was formed inside the vessel 4 to 5 hours later in 80% of cases. SmCo5 magnet was secured externally to one of the arteries. The constant magnetic field produced by the magnet had no influence on the clit formation. Autologous red cells loaded with ferromagnetic colloid compound and aspirin were administered intravenously and completely aborted arteriothrombosis on magnet-suplied side with no deterioratory effect on clot formation in the control artery. © 1990.

引用

页码：611 / 616

页数：6