A NOVEL ORTHO-QUINODIMETHANE STRATEGY FOR AN ACTIVE METABOLITE OF VITAMIN-D3 - A TOTAL SYNTHESIS OF 25-HYDROXY WINDAUS-GRUNDMANN KETONE

被引：37

作者：

NEMOTO, H ^{[1
]}

ANDO, M ^{[1
]}

FUKUMOTO, K ^{[1
]}

机构：

[1] TOHOKU UNIV, INST PHARMACEUT, SENDAI, MIYAGI 980, JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 43期

关键词：

D O I：

10.1016/S0040-4039(00)97025-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly diastereoselective total synthesis of 25-hydroxy Windaus-Grundmann ketone (2) was achieved via a novel regiocontrolled CC bond formation by an intramolecular epoxide ring opening reaction of the bissulfonyl epoxide (19) as a key step, which was derived stereoselectively by the thermolysis of olefinic benzocyclobutene (8) as a key step. © 1990.

引用

页码：6205 / 6208

页数：4

共 13 条

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