TRIIODOTHYRONINE INCREASES RAT APOLIPOPROTEIN-A-I SYNTHESIS AND ALTERS HIGH-DENSITY-LIPOPROTEIN COMPOSITION INVIVO

被引：12

作者：

APOSTOLOPOULOS, JJ ^{[1
]}

MARSHALL, JF ^{[1
]}

HOWLETT, GJ ^{[1
]}

机构：

[1] UNIV MELBOURNE,RUSSELL GRIMWADE SCH BIOCHEM,PARKVILLE,VIC 3052,AUSTRALIA

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 194卷 / 01期

关键词：

D O I：

10.1111/j.1432-1033.1990.tb19438.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of altered serum 3,3′,5‐triiodothyronine levels on rat lipoprotein metabolism were examined. Daily injections of the hormone (50 μg/100 g body mass) over a period of six days led to an increase of 6.4‐fold in the hepatic mRNA level for apolipoprotein(apo)A‐I, and a 21% increase in serum apoA‐I levels. 12 h after a single injection of 3,3′,5‐triiodothyronine the rate of [14C]leucine incorporation into apoA‐I increased 2.1 fold. Conversely, in hypothyroid rats there was a decrease in hepatic mRNA levels for apoA‐I and a decreased rate of [14C]leucine incorporation into apoA‐I. The increase in hepatic apoA‐I mRNA levels following 3,3′,5‐triiodothyronine treatment occurred prior to significant changes in serum triacylglycerol levels. High‐density lipoprotein (HDL) particles isolated from the serum of hyperthyroid rats were smaller and enriched in apoA‐I compared to apoA‐IV and apoE. Similar changes in HDL composition were observed following in vitro incubations of normal rat serum with purified rat apoA‐I. The results suggest that during altered thyroid status, changes in serum HDL size and composition occur in association with significant changes in apoA‐I gene expression. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：147 / 154

页数：8

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