CHARACTERIZATION OF HUMAN THYROTROPIN RECEPTOR RELATED PEPTIDE-LIKE IMMUNOREACTIVITY IN PERIPHERAL-BLOOD OF GRAVES-DISEASE

被引：21

作者：

MURAKAMI, M ^{[1
]}

MIYASHITA, K ^{[1
]}

YAMADA, M ^{[1
]}

IRIUCHIJIMA, T ^{[1
]}

MORI, M ^{[1
]}

机构：

[1] GUNMA UNIV,SCH MED,DEPT INTERNAL MED 1,MAEBASHI,GUNMA 371,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)90856-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An antiserum raised against an alignment of amino acid-(32-56), termed TSHRP-1, in the extracellular domain of human thyrotropin (TSH) receptor was used to identify the TSH receptor-like substance in plasma of Graves' disease. The dilution curve of plasma TSHRP-1-like immunoreactivity was observed in a manner parallel to the standard synthetic peptide curve in radioimmunoassay, and its molecular weight estimated approximately 60 kDa. The amounts of TSHRP-1-like immunoreactivity were significantly higher in Graves' plasma than those in plasma of normal and hypothyroid patients due to Hashimoto's thyroiditis. The present results indicate that human peripheral blood possesses a soluble form of the extracellular domain of TSH receptor which may contribute to the pathophysiology of Graves' disease. © 1992.

引用

页码：1074 / 1080

页数：7

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