MODULATION OF RESPONSES TO TGF-BETA BY 1,25-DIHYDROXYVITAMIN-D-3 IN MG-63 OSTEOBLASTIC CELLS - POSSIBLE INVOLVEMENT OF REGULATION OF TGF-BETA TYPE-II RECEPTOR

被引：22

作者：

IIMURA, T

OIDA, S

ICHIJO, H

GOSEKI, M

MARUOKA, Y

TAKEDA, K

SASAKI, S

机构：

[1] TOKYO MED & DENT UNIV,FAC DENT,DEPT ORAL PATHOL,TOKYO 113,JAPAN

[2] TOKYO MED & DENT UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 1,BUNKYO KU,TOKYO 113,JAPAN

[3] TOKYO MED & DENT UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 2,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2547

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of TGF-beta 1 on the expression of alkaline phosphatase (ALPase) activity was examined during osteoblastic cell line (MG-63) differentiation induced by 1,25-dihydroxyvitamin D-3(1,25D(3)). TGF-alpha 1 and 1.25D(3) were found to enhance ALPase activity. However, preincubation of the cells with 1,25D(3) transiently abolished the effects of TGF-beta 1. Kinetics of the complex responses to TGF-beta 1 and 1,25D(3) were found to correlate well with that of the expression level of type II receptor for TGF-beta. These results suggest that 1,25D(3) may regulate the cellular responses to TGF-beta 1 in part via regulation of functional receptor for TGF-beta (C) 1994 Academic Press, Inc.

引用

页码：918 / 923

页数：6

共 26 条

[1] IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS [J].