REVERSAL OF DAUNOMYCIN AND VINBLASTINE RESISTANCE IN MULTIDRUG-RESISTANT P388 LEUKEMIA IN-VITRO THROUGH ENHANCED CYTOTOXICITY BY TRITERPENOIDS

被引：64

作者：

HASEGAWA, H ^{[1
]}

SUNG, JH ^{[1
]}

MATSUMIYA, S ^{[1
]}

UCHIYAMA, M ^{[1
]}

INOUYE, Y ^{[1
]}

KASAI, R ^{[1
]}

YAMASAKI, K ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,INST PHARMACEUT SCI,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

PLANTA MEDICA | 1995年 / 61卷 / 05期

关键词：

DRUG RESISTANCE; ADRIAMYCIN (ADM)-RESISTANT P388 LEUKEMIA (P388/ADM); PANAX; ARALIACEAE; GLYCYRRHIZA; LEGUMINOSAE; TRITERPENOID; DAUNOMYCIN (DAU); VINBLASTINE (VBL);

D O I：

10.1055/s-2006-958126

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Examined in vitro were the effects of some triterpenoids hom Panax (Araliaceae) and Glycyrrhiza (Leguminosae) spp. on the sensitivity to daunomycin (DAU) and vinblastine (VBL) of adriamycin (ADM)-resistant P388 leukemia cells (P388/ADM), which were resistant to multiple anticancer drugs. Quasipanaxatriol, 20(S)-protopanaxatriol, ginsenoside Rh-2, and compound K greatly enhanced the cytotoxicity of the anticancer drugs in P388/ADM cells. The extent of enhancement was different among the triterpene compounds; the 4- to 46-fold increase in DAU Cytotoxicity was observed in P388/ADM cells in the presence of nontoxic or marginally toxic concentrations of individual compounds, while those for VBL were in the ratios of 2- to 37-fold. The maximum increase in cytotoxicity was observed with 50 mu M quasipanaxatriol; the resistance indices defined to be the ratios of the IC50 values for P388/ADM and P388 parental cells decreased from 79 to 1.7 and from 180 to 4.9 in the cases of DAU and VBL, respectively. The reversal of DAU resistance in P388/ADM by quasipanaxatriol could be explained by the effective accumulation of the drugs mediated by the DAU-efflux blockage.

引用

页码：409 / 413

页数：5

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