EFFECTS OF DM-9384, A PYRROLIDONE DERIVATIVE, ON ALCOHOL-INDUCED AND CHLORDIAZEPOXIDE-INDUCED AMNESIA IN MICE

被引：28

作者：

NABESHIMA, T ^{[1
]}

TOHYAMA, K ^{[1
]}

KAMEYAMA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT HOSP PHARM,NAGOYA,AICHI 466,JAPAN

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1990年 / 36卷 / 02期

关键词：

Amnesia; Benzodiazepines; Bicuculline; Chlordiazepoxide; Ethanol; GABA; GABA[!sub]A[!/sub] receptors; N-(2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384);

D O I：

10.1016/0091-3057(90)90396-Y

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of N- (2,6-dimethyl-phenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide (DM-9384), a new pyrrolidone derivative, were investigated on ethanol- and chlordiazepoxide (CDP)-induced amnesia animal model using the passive avoidance task in comparison with aniracetam, another pyrrolidone derivative. Pretraining administration of DM-9384 attenuated ethanol- and CDP-induced amnesia, whereas aniracetam failed to do so. The effects of DM-9384 on CDP-induced amnesia were antagonized by bicuculline, a GABAA receptor antagonist, but not by scopolamine, a muscarinic acethylcholine receptor antagonist and flumazenil, a benzodiazepine receptor antagonist. These results suggest that DM-9384 attenuates CDP-induced amnesia by interacting with the GABAergic neuronal system. © 1990.

引用

页码：233 / 236

页数：4

共 29 条

[1] AN ANALYSIS OF SOME EFFECTS OF ETHANOL ON PERFORMANCE IN A PASSIVE-AVOIDANCE TASK [J].

BAMMER, G ;

CHESHER, GB .

PSYCHOPHARMACOLOGY, 1982, 77 (01) :66-73

[2] FACILITATION OF MAZE LEARNING WITH POSTTRIAL INJECTIONS OF PICROTOXIN [J].

BREEN, RA ;

MCGAUGH, JL .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1961, 54 (05) :498-&

[3] THE COMPARATIVE EFFECTS OF BENZODIAZEPINES, PROGABIDE AND PK-9084 ON ACQUISITION OF PASSIVE-AVOIDANCE IN MICE [J].

BROEKKAMP, CL ;

LEPICHON, M ;

LLOYD, KG .

PSYCHOPHARMACOLOGY, 1984, 83 (01) :122-125

[4] CLINICAL STUDIES OF INDUCTION AGENTS .25. DIAZEPAM [J].

BROWN, SS ;

DUNDEE, JW .

BRITISH JOURNAL OF ANAESTHESIA, 1968, 40 (02) :108-&

[5] ETHANOL ENHANCES [DIAZEPAM-H-3 BINDING AT THE BENZODIAZEPINE-GABA-RECEPTOR-IONOPHORE COMPLEX [J].

BURCH, TP ;

TICKU, MK .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1980, 67 (2-3) :325-326

[6] AMNESIC EFFECT OF DIAZEPAM (VALIUM) [J].

CLARKE, PRF ;

ECCERSLEY, PS ;

FRISBY, JP ;

THORNTON, JA .

BRITISH JOURNAL OF ANAESTHESIA, 1970, 42 (08) :690-+

[7] EFFECTS OF THE NOVEL COMPOUND ANIRACETAM (RO 13-5057) UPON IMPAIRED LEARNING AND MEMORY IN RODENTS [J].

CUMIN, R ;

BANDLE, EF ;

GAMZU, E ;

HAEFELY, WE .

PSYCHOPHARMACOLOGY, 1982, 78 (02) :104-111

[8]

DAVIS WC, 1981, MOL PHARMACOL, V20, P287

[9]

DAWSON RG, 1973, PHYSL BASIS MEMORY, P78

[10]

FREUND G, 1974, ALCOHOL INTOXICATION, P271

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