EFFECTS OF CHARGE, VOLUME, AND SURFACE ON BINDING OF INHIBITOR AND SUBSTRATE MOIETIES TO ACETYLCHOLINESTERASE

被引：20

作者：

COHEN, SG ^{[1
]}

CHISHTI, SB ^{[1
]}

ELKIND, JL ^{[1
]}

REESE, H ^{[1
]}

COHEN, JB ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1985年 / 28卷 / 09期

关键词：

D O I：

10.1021/jm00147a033

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：1309 / 1313

页数：5

相关论文

共 23 条

[1] ADAMS HD, 1949, BIOCHIM BIOPHYS ACTA, V3, P1
[2] Bondi A., 1968, PHYSICAL PROPERTIES
[3] CARLE JS, 1980, J AM CHEM SOC, V102, P5108
[4] EFFECTS OF VOLUME AND SURFACE-PROPERTY IN HYDROLYSIS BY ACETYLCHOLINESTERASE - THE TRIMETHYL SITE
COHEN, SG
ELKIND, JL
CHISHTI, SB
GINER, JLP
REESE, H
COHEN, JB
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (12) : 1643 - 1647
[5] COHEN SG, 1982, J BIOL CHEM, V257, P4087
[6] ALIPHATIC-KETONES ARE ACETYLCHOLINESTERASE INHIBITORS BUT NOT TRANSITION-STATE ANALOGS
DAFFORN, A
JEWELL, M
ANDERSON, M
ASH, D
HORVATH, D
KITSON, R
MARGIOTTA, S
RYCH, G
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 569 (01) : 23 - 30
[7] DAWSON RM, 1978, J NEUROCHEM, V30, P865
[8] Hansch C, 1979, SUBSTITUENT CONSTANT
[9] HASAN FB, 1981, J BIOL CHEM, V256, P7781
[10] HASAN FB, 1980, J BIOL CHEM, V255, P3898