STEREOCHEMISTRY OF THE KDO8P SYNTHASE - AN EFFICIENT SYNTHESIS OF THE 3-FLUORO ANALOGS OF KDO8P

被引：58

作者：

KOHEN, A ^{[1
]}

BERKOVICH, R ^{[1
]}

BELAKHOV, V ^{[1
]}

BAASOV, T ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,DEPT CHEM,IL-32000 HAIFA,ISRAEL

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80021-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Direct evidence of the overall stereochemistry of the KD08P synthase reaction was obtained by using 3-deuterio and 3-fluoro analogues of phosphoenolpyruvate as alternative substrates and by subsequent H-1 and F-19 NMR analysis of the enzymatic reaction products. The results reveal the si face addition of enzyme-bound phosphoenolpyruvate to the re face of the carbonyl of arabinose 5-phosphate.

引用

页码：1577 / 1582

页数：6

共 21 条

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