IMMUNOSUPPRESSIVE THERAPY IN THE TREATMENT OF IMMUNE-MEDIATED DISEASE

被引：37

作者：

MILLER, E

机构：

[1] Department of Clinical Sciences, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, Colorado

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1992年 / 6卷 / 04期

关键词：

D O I：

10.1111/j.1939-1676.1992.tb00340.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Immune-mediated diseases represent some of the most frustrating types of disorders that are diagnosed and treated in veterinary medicine. Drug-induced immunosuppression is an attempt to control the aberrant immune response against self antigens but the immunosuppression can result in sepsis or other unacceptable adverse effects. If the pathophysiology of immune-mediated and autoimmune disease is considered, the immune response can be divided into several components and attempts can be made to selectively deal with each component separately. The components of the immune response that can be manipulated by therapy include antibodies, effector cells, the mononuclear phagocytic system, and the peripheral manifestations of disease. This article reviews the therapy of immune-mediated and autoimmune diseases based on a pathophysiologic approach and discusses conventional as well as current therapies in the treatment of these devastating diseases.

引用

页码：206 / 213

页数：8

共 57 条

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